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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From February 19, 2008 to May 14, 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< -4.7
Temp.:
20 °C
pH:
ca. 7

The water solubility of Everzol Red CDN Crude was 258 g/l. Taking the dilution factor of the samples into account it corresponds with a solubility of Everzol Red CDN Crude in octanol of < 5 × 10-3g/l. The Pow, calculated as the quotient of the octanol and water solubility, is < 1.9 × 10-5.

Conclusions:
According to OECD 107 and EU Method A.8, the log Pow of Everzol Red CDN Crude was < -4.7.
Executive summary:

This test using the procedures outlined in the NOTOX Study Plan for 487467, OECD 107 and EU Method A.8.

The estimation method was used for the determination of the Pow of Everzol Red CDN Crude. The water solubility of Everzol Red CDN Crude was 258 g/l and a solubility of Everzol Red CDN Crude in octanol of < 5 × 10-3g/l. The Pow, calculated as the quotient of the octanol and water solubility, is < 1.9 × 10-5. Therefore, the log Pow of Everzol Red CDN Crude was < -4.7.

Description of key information

The log Powof Everzol Red CDN Crude was < -4.7 (OECD TG107 and EU Method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
-4.7
at the temperature of:
20 °C

Additional information

The estimation method was used for the determination of the Pow of Everzol Red CDN Crude. The water solubility of Everzol Red CDN Crude was 258 g/l and a solubility of Everzol Red CDN Crude in octanol of < 5 × 10-3g/l. The Pow, calculated as the quotient of the octanol and water solubility, is < 1.9 × 10-5. Therefore, the log Pow of Everzol Red CDN Crude was < -4.7.