Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-816-9 | CAS number: 74-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
There are no data on oral and dermal repeat dose toxicity. Studies are not technically feasible as the substance is a gas at room temperature. The limited data available on a close related substance indicates low toxicity via the inhalation route. It is concluded that there are no adverse effects resulting from repeat dose exposure below the lower explosive limit (LEL) of acetylene (2.5%; 26750 mg/m3).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral and dermal
There are no data on oral and dermal repeat dose toxicity. Studies are not technically feasible as the substance is a gas at room temperature
Inhalation
In consideration of repeat dose toxicity, it is of note that acetylene is metabolised only to a very small extent (~1% if inhaled volume). A highly reactive ketene intermediate may be formed but very rapidly deactivated to acetic acid and it was estimated that no more than 1% of the inhaled amount of acetylene in humans is metabolised to acetate, a natural product (see section 5.1.1 above for further detail). Some repeat-dose studies at anaesthetic concentrations have been reported for acetylene. Excluding the acute effects associated with exposure to acetylene with its well-known anaesthetic and/or asphyxiant properties, there is no evidence of repeat dose toxicity, even at rather high concentrations leading to the conclusion that there are no repeat dose toxicity effects up to the lower explosive limit (LEL) of acetylene.
Justification for classification or non-classification
Due to lack of exposure via the oral or dermal routes (the substance is a gas at room temperature) and very low toxicity following inhalation exposure of a related substance, acetylene does not warrant classification under CLP.
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