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EC number: 200-816-9 | CAS number: 74-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline human experimental study, predates implementation of GLP and/or development of study guidelines. Limitations in reporting but otherwise acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 925
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Subjects were exposed to discontinuous inhalations of acetylene of various concentrations.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acetylene
- EC Number:
- 200-816-9
- EC Name:
- Acetylene
- Cas Number:
- 74-86-2
- Molecular formula:
- C2H2
- IUPAC Name:
- acetylene
- Details on test material:
- - Source: Bon-Accord Acetylene Gas Company
- Prepared from calcium carbide and purified through a lime tower
- No further details
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- No data
- Ethical approval:
- not specified
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- Mixtures of acetylene gas with oxygen were administered from a Douglas bag with the subject in a sitting position and no re-breathing. The concentrations administered were as follows:
0 % to 35 % acetylene: 100,000, 150,000, 200,000, 250,000, 300,000, 330,000 and 350,000 ppm
(50% acetylene caused an unbearable feeling of suffocation within 70 seconds and experiment was stopped) - Examinations:
- - Clinical signs were monitored and the concentration that produced unconsciousness (and exposure time) was listed
- The effects of acetylene inhalation on memory, reflex times and muscular movement were also assessed - Medical treatment:
- No data
Results and discussion
- Clinical signs:
- The lowest concentration employed, 10%, caused feelings of mild intoxication and paraesthesia. 15% caused distinct intoxication and 20% caused marked intoxication after one hour exposure.
- Results of examinations:
- Systemic LOAEC: 1 hour inhalation exposure at 10% (100,000 ppm or 107,000 mg/m3 equivalent) caused mild intoxication and paraesthesia. NOAEC for local irritation: 20% (200,000 ppm, equivalent to 214,000 mg/m3)
Any other information on results incl. tables
The lowest concentration employed, 10%, caused feelings of mild intoxication and paraesthesia.
15% caused distinct intoxication with talkativeness, sleepiness and inability to walk in a straight line.
20% caused marked intoxication after one hour exposure.
25% acetylene caused similar but more marked symptoms.
General uncoordination and aggressive behaviour were noted after inhalation of 30% acetylene for 13 minutes
Inhalation of 33% acetylene caused unconsciousness in 6 - 7 minutes and 35% acetylene in 5 - 5.5 minutes.
50% acetylene produced feelings of intense intoxication within 35 seconds and an unbearable feeling of suffocation in 70 seconds (after which the experiment was stopped).
Incoordination was seen after 4-5, 6, 12-13, 15 and 18 minutes at 35, 33, 30, 25 and 20% respectively.
Unconsciousness occurred at 5 – 5.5 minutes at 35% and 6 – 7 minutes at 33%.
Times of onset of other clinical observations
Conc of Acetylene |
Effects observed |
||||
|
Initial intoxication |
Marked intoxication |
Talkativeness |
Noisy talkativeness |
Aggression |
35% |
25 sec |
60 sec |
1.5 – 2 min |
2.5 – 3 min |
3.5 – 4 min |
33% |
30 sec |
70 sec |
3 min |
3 – 4 min |
5 min |
30% |
30 sec |
90 sec |
3 – 4 min |
4 – 5 min |
8 – 10 min |
25% |
40 sec |
120 sec |
3.5 – 4.5 min |
5 – 6 min |
10 -12 min |
20% |
50 sec |
4 min |
6 min |
11 min |
- |
Applicant's summary and conclusion
- Conclusions:
- Systemic LOAEC: 1 hour inhalation exposure at 10% (100,000 ppm or 107,000 mg/m3 equivalent) caused mild intoxication and paraesthesia. NOAEC for local irritation: 20% (200,000 ppm, equivalent to 214,000 mg/m3)
- Executive summary:
A group of human volunteers was exposed to acetylene at a range of concentrations in order to assess its anaesthetic properties. The lowest concentration employed, 10%, caused feelings of mild intoxication and paraesthesia.
Systemic LOAEC: 1 hour inhalation exposure at 10% (100,000 ppm or 107,000 mg/m3 equivalent).
There was no indication of local irritation effects at 20% for 1 hour (or higher exposures but >20% were less than 1 hour).
NOAEC for local irritation: 20% (200,000 ppm, equivalent to 214,000 mg/m3)
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