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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Turpentine, oil
EC Number:
232-350-7
EC Name:
Turpentine, oil
Cas Number:
8006-64-2
Molecular formula:
UVCB substance molecular formula varied but mainly C10H16, C15H24, C2H6S1, C1H4S1 and C10H18O1
IUPAC Name:
Turpentine Oil from Pulping Processes (TOPP) is a volatile oil extracted from various tree species. It consists of terpenes, mainly bicyclic monoterpenes such as alpha- and beta-pinene and delta-3-carene, and lower concentrations of monocyclic monoterpenes.
Details on test material:
- Name of test material (as cited in study report): Compound number 71-2-85 (turpentine oil)

- Physical state: clear liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24h
Doses:
2000 mg/kg
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

No animals died during the course of the study. No evidence of toxicity from percutaneous absorption of the test material. Moderate erythema was present in 1 animal and slight erythema in 8 animals on day one, which was completely reversible in all animals by day 5. Moderate edema was present in one animal on day one and slight edema in 4 animals, all effects reversible by day 3. All animals were essentially normal by the termination of the study. No abnormalities were noted at necropsy.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal toxicity study in New Zealand White rabbits, the LD50 was >2000 mg/kg.

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