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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
The information is taken from a peer reviewed publication. No study details are available therefore reliability cannot be assigned.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicology of the Eye
Author:
Grant, WM
Year:
1974
Bibliographic source:
Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, cited in HSDB (courtesy of Charles C Thomas Publisher, Ltd, Springfield, Illinois).
Report date:
1974
Reference Type:
secondary source
Title:
No information
Bibliographic source:
Hazardous Substances DataBank, US National Library of Medicine

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No information available on method.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Turpentine, oil
EC Number:
232-350-7
EC Name:
Turpentine, oil
Cas Number:
8006-64-2
Molecular formula:
UVCB substance molecular formula varied but mainly C10H16, C15H24, C2H6S1, C1H4S1 and C10H18O1
IUPAC Name:
Turpentine oil from pulping processes
Constituent 2
Reference substance name:
Turpentine
EC Number:
232-688-5
EC Name:
Turpentine
IUPAC Name:
Turpentine
Details on test material:
No details available.

Test animals / tissue source

Species:
other: no data
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No information available.

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
No information.
Duration of treatment / exposure:
No information.
Observation period (in vivo):
No information.
Number of animals or in vitro replicates:
No information.
Details on study design:
No information.

Results and discussion

In vivo

Results
Remarks on result:
other: No irritation scores reported.
Irritant / corrosive response data:
No irritation scores reported.
Other effects:
Subconjunctival injection of turpentine in one case caused Phthisis bulbi. Injection into anterior chamber of animals causes fibrinopurulent inflammation with corneal opacification from endothelial injury and infiltration of leukocytes.

Applicant's summary and conclusion

Interpretation of results:
irritating
Conclusions:
Adverse ocular effects (no scores provided) are reported in a peer reviewed publication. Turpentine is classified as an eye irritant in Annex VI of Regulation 1272/2008/EC.