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Long-term toxicity to aquatic invertebrates

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long-term toxicity to aquatic invertebrates
Data waiving:
study scientifically not necessary / other information available
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Description of key information

No measured data are available for long-term toxicity of TOPP to aquatic invertebrates. TOPP is a UVCB substance and a data-waiver is considered to be appropriate for this endpoint on the grounds that, in accordance with Section 1 of REACH Annex XI (EC 2006), the study does not need to be conducted because the needs associated with obtaining a sound understanding of long-term toxicity to invertebrates are adequately met by the available data on constituents. Compositional information has been used in conjunction with validated QSARs to derive No Observed Effect Concentrations (NOECs) for TOPP constituent blocks. Calculation of PNECs for the aquatic compartment will be based on the block NOECs rather than on data for the whole substance. Testing for long-term toxicity to invertebrates will therefore not contribute to the database that is required to complete the assessment of the substance.

NOEC values of 0.0025 and 0.46 mg/l have been reported for the effects of dimethyl disulfide (CAS 624-92-0) to Daphnia magna and Americamysis bahia.

Key value for chemical safety assessment

Additional information