Registration Dossier
Registration Dossier
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EC number: 200-539-3 | CAS number: 62-53-3
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Reproduction
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Hardin, B.D. et al., Teratogen. Carcinogen. Mutagen. 7,|29-48 (1987)
- Title:
- No information
- Author:
- Piccirillo, V.J. et al., Screening of priority chemicals|for reproductive hazards (NTIS report no. PB83-257600).|Borriston Labs., Inc., Temple Hills (1983)
Materials and methods
Test material
- Reference substance name:
- Aniline
- EC Number:
- 200-539-3
- EC Name:
- Aniline
- Cas Number:
- 62-53-3
- Molecular formula:
- C6H7N
- IUPAC Name:
- aniline
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- Exposure period: 8 d
- Frequency of treatment:
- day 7 through day 14 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 or 560 mg/kg bw
Basis:
- Control animals:
- yes
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
I. dams:
An increased mortality (6/50) and a significantly lower
than control mean weight change was noted, but no adverse
effects on reproductive outcome was observed.
II. fetuses:
A reduced birth weight, decreased weight gain and a reduced
offspring viability through the first 3 postpartum days was
noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
