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EC number: 915-037-6
CAS number: -
All acute inhalation studies performed with dry dust were hampered by
the technical problem to achieve the recommended highest test
concentration of 5 mg/l, apparently attributable to the high adhesive
forces which caused rapid precipitation onto equipment walls. Therefore,
the maximum attainable chamber concentrations were distinctly lower than
the available studies on acute toxicity of silica after inhalation.
Following inhalation exposure of rats to the highest technically
feasible concentrations of 140 to ca. 2000 mg/m3synthetic
amorphous silica, no lethal effects were observed. The acute inhalation
of synthetic amorphous silica dust may cause discomfort and stress as
well as signs of local irritation to nasal, bronchiolar and ocular
mucous membranes. In conclusion, the synthetic amorphous silica dusts
are considered acutely non-toxic via the inhalation route.
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