Registration Dossier
Registration Dossier
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EC number: 915-037-6 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There is no data on mutagenicity of silicocalcium. Therefore, read-across approach is utilised. This means the use of information on the mutagenicity of related compounds - such as calcium silicate, which has similar order of water solubility, and releases silicon and calcium.
In vivo and in vitro studies on the mutagenicity of amorphous silicas have not shown relevant positive responses and thus amorphous silica seems to be non-genotoxic. The genetic toxicity of calcium silicate has been tested both in vitro and in vivo,and it has given negative results.
The conclusion is that CaSi can be regarded as likely nongenotoxic.
Short description of key information:
Based on read-across data from silcia and silicates, there are no indications of genotoxicity. The conclusion is that CaSi can be regarded as likely nongenotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Conclusion: No classification for mutagenicity or further testing is suggested.
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