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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline-compliant investogation of ocular irritation performed as part of a larger investigation of toxicokinetics.

Data source

Reference
Reference Type:
publication
Title:
Absorption, Distribution and Excretion of Terephthalic Acid and Dimethyl Terphthalate
Author:
Moffitt, A.E., Clary, J.J., Lewis, T.R., Blanck, M.D. and Perone, V.B.
Year:
1975
Bibliographic source:
American Industrial Hygiene Association Journal, 36(8), 633-41 (1975)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: US FDA Test for eye irritants (21CFR Part 191), 1964
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Dimethylterephthalate
IUPAC Name:
Dimethylterephthalate

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Albino rabbits: no further data reported

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
A single dose of 50 mg DMT was instilled into the conjunctival sac one eye of 8 rabbits. The eyes were washed with water after five minutes or 24 hours.
Observation period (in vivo):
10 days
Number of animals or in vitro replicates:
8
Details on study design:
A single dose of 50 mg DMT was instilled into the conjunctival sac one eye of 8 rabbits. The eyes were washed with water after five minutes or 24 hours.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: All
Score:
0
Max. score:
0
Remarks on result:
other: No effects are reported
Irritant / corrosive response data:
No evidence of ocular damage was seen in this study.
Other effects:
The toxicokinetics of the substance following ocular administration were also investigated and are reported elsewhere.

Any other information on results incl. tables

None.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No evidence of ocular irritation was reported in this study.
Executive summary:

In a guideline-compliant study, a single dose of 50 mg DMT was instilled into the conjunctival sac one eye of 8 rabbits. The eyes were washed with water after five minutes or 24 hours. No evidence of ocular irritation was reported.