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EC number: 204-411-8 | CAS number: 120-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 38 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted prior to institution of Good Laboratory Practices. The study was conducted by an internal Eastman Kodak Company method, developed prior to established guidelines, but was in accord with acceptable scientific standard methods in use at the time the study was conducted. The results of this study are valid for classification insofar as the conditions of exposure are at least as stringent as modern guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of 5-10 guinea pigs were used to determine the dermal sensitization potential of the test substance using the Kodak Drop-on method. The irritant potential of a 1% solution of the substance in a 7:2:1 mixture of acetone, dioxane, and guinea pig fat was determined 24 and 48 hours following application to the clipped back skin of ten animals. Three additional applications of this solution were applied over the next five days. The animals were allowed to rest for three weeks. Challenge doses of the test solution were then made on one shoulder of the guinea pigs, and one week later, on the other shoulder. The results of the first application were compared to the resuts of the last application to determine the sensitization potential of the test material. An additional group of five animals was treated with the solvent mixture alone and was used as a control. The responses were quantified using a four point scale based on responses that were negative, slight, moderate, or strong.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP
- Type of study:
- other: Study conducted according to an internal Eastman Kodak Company laboratory method, known as the drop-on method, not used elsewhere.
Test material
- Reference substance name:
- Dimethyl terephthalate
- EC Number:
- 204-411-8
- EC Name:
- Dimethyl terephthalate
- Cas Number:
- 120-61-6
- Molecular formula:
- C10H10O4
- IUPAC Name:
- dimethyl terephthalate
- Reference substance name:
- dimethyl 1,4-benzenedicarboxylate; dimethyl p-benzenedicarboxylate; dimethyl p-phthalate; methyl 4-carbomethoxybenzoate; methyl p-(methoxycarbonyl)benzoate; terephthalic acid, dimethyl ester
- IUPAC Name:
- dimethyl 1,4-benzenedicarboxylate; dimethyl p-benzenedicarboxylate; dimethyl p-phthalate; methyl 4-carbomethoxybenzoate; methyl p-(methoxycarbonyl)benzoate; terephthalic acid, dimethyl ester
- Details on test material:
- -Test substance: Dimethyl terephthalate
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: Both irritation/induction and challenge phases: 7:2:1 acetone:dioxane:guinea pig fat
- Concentration / amount:
- Preliminary Irritation and Induction Phase: 1.0% in acetone + dioxane + guinea pig fat (7:2:1).
Challenge Phase: 1.0% in acetone + dioxane + guinea pig fat (7:2:1).
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: Both irritation/induction and challenge phases: 7:2:1 acetone:dioxane:guinea pig fat
- Concentration / amount:
- Preliminary Irritation and Induction Phase: 1.0% in acetone + dioxane + guinea pig fat (7:2:1).
Challenge Phase: 1.0% in acetone + dioxane + guinea pig fat (7:2:1).
- No. of animals per dose:
- 10
- Details on study design:
- Groups of 10 guinea pigs were used to determine the dermal sensitization potential of the test substance using the Kodak Drop-on method. Initially, the irritant potential of a 1% solution of the substance in a 7:2:1 mixture of acetone, dioxane, and guinea pig fat was determined following application to the clipped back skin of the animals. Based on the response, the 1% concentration was used for the entire study. Three additional applications of this solution were applied over the next five days. The animals were allowed to rest for three weeks. Challenge doses of the test solution were then made on one shoulder of the guinea pigs, and one week later, on the other shoulder. The results of the very first application were compared to the resuts of the last application to determine the sensitization potential of the test material. An additional group of five animals was treated with the solvent mixture alone and was used as a control. The responses were quantified using a four point scale based on responses that were negative, slight, moderate, or strong. The total erythema scores and total edema scores from all ten animals receiving 1% compound in the solvent were added together and divided by 10 to obtain an irritant score. This was done for both the 24-hour and 48-hour observations. Total erythema and edema scores were obtained from the five solvent control animals as well. The differences in the scores were an indication of the sensitization response, if any.
- Positive control substance(s):
- yes
- Remarks:
- Phenylhydrazine
Study design: in vivo (LLNA)
- Statistics:
- no data
Results and discussion
- Positive control results:
- Phenylhydrazine was used as a positive control in the series of studies. A dilute solution of this positive control substance was repeatedly applied in the acetone: dioxane: guinea pig fat solvent to the skin of five guinea pigs. The results of this study demonstrated that repeated application of the positive control caused a significant sensitization response in guinea pigs in the test laboratory.
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Group:
- other: solvent control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- The average response in the 5 animals at 24 hours (erythema + edema) following the initial application was 1.2.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. Group: other: solvent control. Dose level: 0%. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: The average response in the 5 animals at 24 hours (erythema + edema) following the initial application was 1.2..
- Reading:
- 2nd reading
- Group:
- other: solvent control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- The average response in the 5 animals at 24 hours (erythema + edema) following the initial application was 1.2.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. Group: other: solvent control. Dose level: 0%. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: The average response in the 5 animals at 24 hours (erythema + edema) following the initial application was 1.2..
- Reading:
- 1st reading
- Group:
- other: solvent control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- The average response in the 5 animals at 24 hours (erythema + edema) following the final application was 1.2.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. Group: other: solvent control. Dose level: 0%. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: The average response in the 5 animals at 24 hours (erythema + edema) following the final application was 1.2..
- Reading:
- 2nd reading
- Group:
- other: solvent control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- The average response in the 5 animals at 48 hours (erythema + edema) following the final application was 1.2.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. Group: other: solvent control. Dose level: 0%. No with. + reactions: 0.0. Total no. in groups: 5.0. Clinical observations: The average response in the 5 animals at 48 hours (erythema + edema) following the final application was 1.2..
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- The average response in the 10 animals at 24 hours (erythema + edema) following the initial application was 1.1.
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: The average response in the 10 animals at 24 hours (erythema + edema) following the initial application was 1.1..
- Reading:
- 2nd reading
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- The average response in the 10 animals at 48 hours (erythema + edema) following the initial application was 1.2.
- Remarks on result:
- other: Reading: 2nd reading. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: The average response in the 10 animals at 48 hours (erythema + edema) following the initial application was 1.2..
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- The average response in the 10 animals at 24 hours (erythema + edema) following the final application was 1.3.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: The average response in the 10 animals at 24 hours (erythema + edema) following the final application was 1.3..
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- The average response in the 10 animals at 48 hours (erythema + edema) following the final application was 1.2.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: The average response in the 10 animals at 48 hours (erythema + edema) following the final application was 1.2..
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Dimethyl terephthalate is not considered to be a skin sensitizer using the Kodak Drop-on Method. Based on an absence of positive effects in this study, this material is not classifiable for Skin Sensitization according to UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
- Executive summary:
In a study on dimethyl terephthalate using the Kodak Drop-on Method, a group of ten guinea pigs was treated with multiple topical applications of 0.5 mL of a 1.0% solution of the test substance in acetone + dioxane + guinea pig fat (7:2:1). After a three-week rest period, the animals were treated again with the solution on one shoulder and one week later, on the other shoulder . The final observations were compared to the initial observations to determine potential sensitization by the test material. A group of five control guinea pigs was treated with only the solvent mixture. Twenty-four and forty-eight hours after challenge, the reactions in the control and test groups were similar. Based on the results of this study using the Kodak Drop-on Method, it was determined that dimethyl terephthalate was a not a dermal sensitizer.
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