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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
other: data sharing dispute
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data sharing dispute

Data source

Reference
Reference Type:
other: not specified
Title:
Metabolism of L (+) - and D (-) - tartaric acids in different animal species
Author:
Gry J & Larsen JG
Year:
1978
Bibliographic source:
N.A.

Materials and methods

Principles of method if other than guideline:
data sharing dispute

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Main ADME resultsopen allclose all
Type:
excretion
Results:
rats and guinea pigs handle the compound in different ways, the pig held an intermediate position in the ability to excrete the tartaric acids.
Type:
excretion
Results:
only in the rat was there a difference in the ability to excrete the two isomers, with a lower recovery of the D(-)-form.
Type:
metabolism
Results:
the in vitro study showed that no difference of decomposition of tartaric acid by the intestinal flora between guinea pig and rat.

Applicant's summary and conclusion