Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-766-0
CAS no.:
87-69-4
Index number:
Molecular formula:
C4H6O6
SMILES:
O[C@H]([C@@H](O)C(O)=O)C(O)=O
InChI:
InChI=1/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/s2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
20
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance causes serious eye damage.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if swallowed, may cause respiratory irritation, causes skin irritation and may cause an allergic skin reaction.

Breakdown of all 4712 C&L notifications submitted to ECHA

Eye Irrit. 2 H319
STOT SE 3 H335
Skin Irrit. 2 H315
Acute Tox. 4 H302
Skin Sens. 1 H317
Eye Dam. 1 H318
Not Classified
Skin Corr. 1 H314
Aquatic Chronic 3 H412
Skin Corr. 1A H314
Acute Tox. 3 H301
Eye Irrit. 2A H319
Met. Corr. 1 H290
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 18 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved in the EEA and/or Switzerland for use in biocidal products more favourable for the environment, human or animal health. It is an authorised food additive.

This substance is used in the following products: cosmetics and personal care products, washing & cleaning products, perfumes and fragrances and fillers, putties, plasters, modelling clay.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).

This substance is used in the following products: cosmetics and personal care products, fillers, putties, plasters, modelling clay, perfumes and fragrances and photo-chemicals.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: food products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes, laboratory work and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: adhesives and sealants, fillers, putties, plasters, modelling clay, pH regulators and water treatment products, laboratory chemicals, paper chemicals and dyes, perfumes and fragrances, photo-chemicals, cosmetics and personal care products and pharmaceuticals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: adhesives and sealants, pH regulators and water treatment products, metal surface treatment products, photo-chemicals, fillers, putties, plasters, modelling clay, laboratory chemicals, perfumes and fragrances, pharmaceuticals and cosmetics and personal care products.

This substance is used in the following areas: building & construction work, formulation of mixtures and/or re-packaging and health services. This substance is used for the manufacture of: food products, chemicals and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, laboratory work, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: as processing aid, in processing aids at industrial sites, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Alvinesa Natural Ingredients, S.A, Ctra. Valdepeñas, Km. 4,85 Apdo. de Correos, 16 13250 Daimiel Ciudad Real Spain
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • B-Lands Consulting (811232-9), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • Caviro Extra SpA con SU, Via Convertite 8 48018 Faenza Ravenna Italy
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Comercial Quimica Sarasa S.L., Ctra. Estremera km 2.5 28597 Fuentiduena de Tajo Madrid Spain
  • Distillerie BONOLLO SpA, Via Mosca 5 41043 Formigine Modena Italy
  • Distillerie Mazzari Spa, Via giardino, 6 48020 S.Agata sul Santerno (RA) Italy
  • GIOVANNI RANDI SPA, Via Spallanzani 7 48018 Faenza Emilia Romagna Italy
  • Industria Chimica Valenzana S.p.A., Via Desman, 428 35010 Borgoricco Italy
  • INOSUD SAS, vessane 30360 CRUVIERS-LASCOURS France
  • Intertek Deutschland GmbH CHBB, Stangenstr.1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • PAHI SL, Av Marid 66 08028 Barcelona Catalonia Spain
  • Penetron Hellas S.A., 50 Thrakomakedonon Av. 13679 Acharnes Attiki Greece
  • PROCOS SpA, via Matteotti 249 28062 Cameri Piemonte Italy
  • RFI Food Ingredients Handelsgesellschaft mbH, Kennedydamm 24 40476 Duesseldorf NRW Germany
  • SAS Tartric-Med, 431, rue Philippe Lamour Distillerie des Costières 30600 Vauvert France
  • VILLAPANA SPA, Via Pana 238-244 48018 Faenza Emilia Romagna Italy
  • IVICT Europe GmbH, Kennedydamm 19 40476 Düsseldorf Germany
  • PRODUCTOS CAPILARES L'OREAL S.A., Calle Lopez Bravo n°78 Poligono Industrial Villalonquéjar 09001 BURGOS Spain
  • Reach Only Representative Ltd (genbes), Booths Park 1 Chelford Road WA16 8GS Knutsford Cheshire United Kingdom
  • WeylChem Lamotte S.A.S, Rue du Flottage B.P. 1 60350 Trosly Breuil France

Substance names and other identifiers

(+)-(R,R)-Tartaric acid
Other
(+)-tartaric acid
EC Inventory, REACH pre-registration, Other
(+)-Tartaric acid
Biocidal active substances, REACH pre-registration, Other
(2R,3R)-(+)-Tartaric acid
Other
1,2-Dihydroxyethane-1,2-dicarboxylic acid
Other
2,3-Dihydroxybutanedioic acid
Other
Acidum tartaricum
Other
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-
Other
Cichoric acid
Other
d-alpha,beta-Dihydroxysuccinic acid
Other
Dextrotartaric acid
Other
Kyselina 2,3-dihydroxybutandiova
Other
Kyselina vinna
Other
L-(+)-Tartaric acid
Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
l-Tartaric acid
Food Contact Regenerated Cellulose Directive - Authorised Substances
Natural tartaric acid
Other
Succinic acid, 2,3-dihydroxy
Other
Tartaric acid
Other
Tartaric acid (VAN)
Other
Tartaric acid, L-(+)-
Other
Threaric acid
Other
(+)-Borkősav (hu)
Biocidal active substances
(+)-Kwas winowy (pl)
Biocidal active substances
(+)-kyselina vinná (cs)
Biocidal active substances
(+)-Tartaric acid (no)
Biocidal active substances
(+)-viinhape (et)
Biocidal active substances
(+)-Viinihappo (fi)
Biocidal active substances
(+)-vinska kiselina (hr)
Biocidal active substances
(+)-Vinska kislina (sl)
Biocidal active substances
(+)-Vinsyra (sv)
Biocidal active substances
(+)-vinsyre (da)
Biocidal active substances
(+)-Vyno rūgštis (lt)
Biocidal active substances
(+)-Vīnskābe (lv)
Biocidal active substances
(+)-Weinsäure (de)
Biocidal active substances
(+)-Wijnsteenzuur (nl)
Biocidal active substances
(+)-Ácido tartárico (pt)
Biocidal active substances
(+)-Τρυγικό οξύ (el)
Biocidal active substances
(+)-Винена киселина (bg)
Biocidal active substances
Acid (+)-tartric (ro)
Biocidal active substances
Acide (+)-tartrique (fr)
Biocidal active substances
Acido (+)-tartarico (it)
Biocidal active substances
Aċidu (+)-tartariku (mt)
Biocidal active substances
Kyselina (+)-vínna (sk)
Biocidal active substances
Ácido (+)-tartárico (es)
Biocidal active substances
(+) Tartaric acid
C&L Inventory, Registration dossier
(+)-Tartaric acid
C&L Inventory
(2R,3R)-(+)-Tartaric acid
C&L Inventory
(2R,3R)-2,3-dihydroxybutanedioic acid
C&L Inventory, Registration dossier, Other
(2R,3R-2,3-Dihydroxybutandisäure
C&L Inventory
2,3-dihydroxy butanedioic acid
C&L Inventory
2,3-dihydroxybutanedioic acid
C&L Inventory
2,3-Dihydroxysuccinic acid
C&L Inventory, Registration dossier
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-
C&L Inventory
Butanedioic acid, 2,3-dihydroxy- (R-(R,R))-
C&L Inventory
Bórkősav
C&L Inventory
L(+) Tartaric Acid
Registration dossier
L(+)-2,3-dihydrooxy butanedioic acid
C&L Inventory
L(+)-Tartaric acid
C&L Inventory
L-(+)-Tartaric Acid
C&L Inventory
L-(+)-Tartaric acid
C&L Inventory, Registration dossier
tartaric
C&L Inventory
Tartaric Acid
C&L Inventory, Registration dossier
Tartaric Acid
C&L Inventory, Registration dossier
Tartaric acid (d,l)
C&L Inventory
(+)-tartaric acid
Registration dossier
Acide tartrique
Registration dossier
ACIDO TARTARICO
C&L Inventory
L-(+)-Tartaric acid
Registration dossier
Tartaric acid
Registration dossier
1039646-76-8
CAS number
Other
1334703-49-9
CAS number
Other
1336-18-1
CAS number
Other
1488329-53-8
CAS number
Other
2088032-42-0
CAS number
Other
8014-54-8
CAS number
Other
8059-77-6
CAS number
Other
87-69-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Food Contact Regenerated Cellulose Directive - Authorised Substances

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 23 studies submitted
  • 23 studies processed
C Physical state at 20°C and 1013 hPa
Solid (96%) [23]
C Form
Crystalline (56%), Powder (40%) [25]
C Odour
Odourless (100%) [3]
C Substance type
Organic (100%) [23]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 19 2
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: crystalline (100%)
Colour
white (100%)

Melting/freezing point

Study results
  • 18 studies submitted
  • 17 studies processed
R Melting / freezing point
70 - 230 °C @ 101.325 kPa [17]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence 15
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 7 studies submitted
  • 7 studies processed
R Boiling point
130 - 600 °C @ 101 - 101.325 kPa [7]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 5 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 24 studies submitted
  • 22 studies processed
R Density
1.666 - 1.984 g/cm³ @ 18 - 25 °C [21]
R Relative density
1.878 @ 20.6 °C [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 22
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 5 studies submitted
  • 5 studies processed
R Vapour pressure
0 - 5 Pa @ 20 - 50 °C [6]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 5 studies processed
R Pow
0.012 @ 20 °C [1]
R Log Pow
-3.7 - -0.76 @ 20 - 25 °C and pH 2 - 9 [7]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 30 studies submitted
  • 30 studies processed
R Water solubility (mass/vol.)
400 - 1 849 000 mg/L @ 6 - 100 °C and pH 1.27 - 9 [37]

Type of Study provided
Studies with data
Key study 6 1
Supporting study
Weight of evidence 22 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 4 studies processed
R Flash point
100 - 210 °C @ 101.325 - 102.3 kPa [4]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
375 - 425 °C @ 101.325 - 101.5 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 12 studies submitted
  • 2 studies processed
R pH
6.5 - 8.5 @ 20 - 25 °C and 1.47 - 50 g/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 12
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 11 studies submitted
  • 11 studies processed
C Dissociating properties
Yes (100%) [11]
R Dissociation constant
2.93 - 4.91 @ 15 - 25 °C [21]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 11
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 5 studies processed
R BOD5
401 - 409 mg O2/g test material [2]
C Interpretation of results
Readily biodegradable (100%) [5]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (2)
Intermittent releases (freshwater) No hazard identified (2)
Marine water No hazard identified (2)
Intermittent releases (marine water) No hazard identified (2)
Sewage treatment plant (STP) No hazard identified (2)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil No exposure of soil expected (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 100 - 1 385.96 mg/L [4]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
NOEC (30 days) 43.141 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
EC50 (48 h) 93.313 - 265 000 mg/L [2]
IC50 (24 h) 135 mg/L [1]
IC50 (24 h) 899 µmol/L [1]
LC50 (48 h) 538.36 - 766.22 mg/L [2]
EC0 (32 h) 135 mg/L [1]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 2
Weight of evidence 2 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 167 g/L [1]
EC50 (72 h) 51.404 - 100 mg/L [3]
IC50 (72 h) 600 mg/L [1]
NOEC (72 h) 3.125 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
167 g/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 1 g/L [1]
IC50 (48 h) 4.783 g/L [1]
EC10 (3 h) 1 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1 g/L
EC10 or NOEC for microorganisms
1 g/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (Low hazard (no threshold derived)) -
Acute /short term: (Low hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (Low hazard (no threshold derived)) -
Acute /short term: (Low hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study
Weight of evidence 20 6
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 34 studies submitted
  • 24 studies processed
P/RResults
LD50 920 - 5 000 mg/kg bw (rat) [5]
LD50 4 109 mg/kg bw (mouse) [1]
LD100 5 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Category 5 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 2 1
Supporting study 4 4
Weight of evidence 23
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other 1
dermal
  • 6 studies submitted
  • 6 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [5]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
other routes
  • 19 studies submitted
  • 2 studies processed
P/RResults
LD50 200 - 500 mg/kg bw (mouse) [5]
rabbit 200 - 500 mg/kg bw (mouse) [1]

other routes
Studies with data
Key study
Supporting study
Weight of evidence 19
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3 1
Supporting study 1
Weight of evidence 1 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irreversible damage)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 21 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 2 460 - 3 200 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 3 7
Weight of evidence 8
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 2 460 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study
Weight of evidence 24 1 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: in vivo
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study
Weight of evidence 9
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 1
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: developmental
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 9
Weight of evidence 5
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant