Registration Dossier
Registration Dossier
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EC number: 204-469-4 | CAS number: 121-44-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The LC50 (96h) value of 24 mg/L is used for the CSA (worst case approach).
Beside the reported key value, a NOEC(96h) of 16 mg/L was determined by Springborn Laboratories (1994).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 24 mg/L
Additional information
The acute toxicity of the test substance towards the freshwater fish Oryzias latipes was investigated by the Ministry of the Environment in Japan (1999a) according to OECD Guideline 203. As final result, a LC50(96h) value of 24 mg/L was reported.
Furthermore, the acute toxicity of the test substance towards the freshwater fish Oncorhynchus mykiss was investigated by Machado (1994) according to the Test Guideline 797.1400 (US EPA, 1985) and the Standard Guide for Conducting Acute Toxicity Tests with Fishes, Macroinvertebrates, and Amphibians (ASTM, 1993) in compliance with GLP. The nominal test concentrations were 0 (control), 4.7, 7.8, 13, 22, 36 and 60 mg/L.
Based on mean measured test concentrations, the LC50 (96h) value was determined as 36 mg/L while the NOEC (96h) amounts to 16 mg/L.
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