Registration Dossier
Registration Dossier
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EC number: 204-469-4 | CAS number: 121-44-8
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: does not meet criteria of current guidelines; mixture tested
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Schweinsberg F. et al.
- Year:
- 1 972
- Bibliographic source:
- Hoppe-Seylers Z. Physiol. Chem. 353,|1671-76 (1972)
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Triethylamine-Hydrochloride and sodium nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- SIV 50
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 1 year
- Frequency of treatment:
- continuous in feed
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5% Triethylamine-Hydrochloride plus 0.5% sodium nitrate
Basis:
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Results of examinations
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- No toxicity or development of tumors was observed. The authors assume that in spite of the large dose, the Nitrosamine production is insuffcient to be tumorigenic.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
