Registration Dossier
Registration Dossier
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EC number: 204-469-4 | CAS number: 121-44-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The following experimental results were obtained in context of acute toxicity to aquatic invertebrates:
Ceriodaphnia dubia: LC50(48h) = 17 mg/L; NOAEC (48h) = 12 mg/L (Collins, 1994).
Daphnia magna: EC50(48h) = 200 mg/L (Bringmann and Kuhn, 1959)
Daphnia magna: EC50(48h) = 34 mg/L (Ministry of the Environment in Japan, 1999)
Key value for chemical safety assessment
Additional information
Ceriodaphnia dubia was used to determine the acute aquatic toxicity of the test substance according to the Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms (US EPA, 1991) and to the Standard Guide for Conducting Acute Toxicity Tests with Fishes, Macroinvertebrates, and Amphibians (ASTM, 1993) in compliance with GLP (Collins, 1994). The nominal concentrations chosen for the definitive test were 1.6, 3.1, 6.3, 13 and 25 mg/L. The basis for effect was mortality within 48 hours. Based on the mean measured concentrations, TEA resulted in a LC50 (48 h) of 17 mg/L and a NOAEC (48h) of 12 mg/L.
Furthermore, the acute toxicity of the test substance towards Daphnia magna was investigated by Bringmann and Kuhn (1959). The test procedure was similar to the one described by OECD Guideline 202. The test organisms were exposed for 48 h while any abnormal behaviour were observed. As a result, the EC50 (48h) is reported as 200 mg/L.
The Ministry of the Environment in Japan (1999b) also investigated the acute toxicity towards the freshwater invertebrate Daphnia magna. The experimental conditions were in accordance with OECD Guideline 202. As final result, an EC50 (48h) value of 36 mg/L is reported.
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