Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Principles of method if other than guideline:
other: measured
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
cyclohexanol; cyclohexanone
EC Number:
906-627-4
Molecular formula:
Unspecified
IUPAC Name:
cyclohexanol; cyclohexanone
Details on test material:
Name of test material (as cited in study report): Anolone, a mixture containing 53.6 % (w/w) of cyclohexanol, 42.0 % (w/w) of cyclohexanone, and 4.4 % (w/w) unknown substances.
Analytical purity: pure

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.05
Temp.:
25 °C
Remarks on result:
other: pH value not relevant. The test substance does not contain any ionic structure.

Any other information on results incl. tables

The partition coefficient of anolone-mixture:
-----------------------------------------
/ P(OW) / log P(OW) /
1. Weighed sample / 12.1 / 1.08 /
2. Weighed sample / 11.0 / 1.04 /
3. Weighed sample / 10.6 / 1.03 /

Mean / 11.2 / 1.05 /

Standard deviation +/- 0.7

The partition coefficient of anolone-mixture in 1-Octanol/Water at 25 °C: log Pow = 1.05


Partition ceofficient of cylohexanone:
----------------------------------------
/ P(OW) / log P(OW) /
1. Weighed sample / 8.3 / 0.92 /
2. Weighed sample / 7.3 / 0.87 /
3. Weighed sample / 6.4 / 0.80 /

Mean / 7.3 / 0.86 /

Standard deviation +/- 1.0

The partition coefficient of cylohexanone in 1-Octanol/Water at 25 °C: log Pow = 0.86


Partition ceofficient of cyclohexanol:
----------------------------------------
/ P(OW) / log P(OW) /
1. Weighed sample / 18.6 / 1.27 /
2. Weighed sample / 18.3 / 1.26 /
3. Weighed sample / 16.9 / 1.23 /

Mean / 17.9 / 1.25 /

Standard deviation +/- 0.9

The partition coefficient of cylohexanol in 1-Octanol/Water at 25 °C: log Pow = 1.25

Applicant's summary and conclusion