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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without detailed documentation (study written in swedish)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Details on test material:
- Name of test material (as cited in study report): cyclohexanol
- Analytical purity: 99%

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 + 3°C
- Humidity (%): 50 + 20 %
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Duration of treatment / exposure:
4 sek; 30sek; 24h
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
3
Details on study design:

SCORING SYSTEM:
Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
1.9
Max. score:
4
Reversibility:
fully reversible within: 10 days
Remarks on result:
other: Mean (24,48; 72h) scores of each animal: animal #1 = 1.7; animal #2 = 2; animal #3 = 2
Irritation parameter:
iris score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
0
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
conjunctivae score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
2.1
Max. score:
4
Reversibility:
fully reversible within: 10 days
Irritation parameter:
chemosis score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
2.3
Max. score:
4
Reversibility:
fully reversible within: 10 days

Any other information on results incl. tables

As the erythema and edema scores resulting from the 4sec- and 30sec-exposure are less relevant for an assessment of the eye irritating property of the substance, the details are not reported here.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information

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