Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 906-627-4 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation (study written in swedish)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohexanol
- EC Number:
- 203-630-6
- EC Name:
- Cyclohexanol
- Cas Number:
- 108-93-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- cyclohexanol
- Details on test material:
- - Name of test material (as cited in study report): cyclohexanol
- Analytical purity: 99%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
-
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 + 3°C
- Humidity (%): 50 + 20 %
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Duration of treatment / exposure:
- 4 sek; 30sek; 24h
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
-
SCORING SYSTEM:
Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (24h exposure)
- Basis:
- mean
- Remarks:
- for each of 3 animals
- Time point:
- other: 24;48;72h
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- other: Mean (24,48; 72h) scores of each animal: animal #1 = 1.7; animal #2 = 2; animal #3 = 2
- Irritation parameter:
- iris score
- Remarks:
- (24h exposure)
- Basis:
- mean
- Remarks:
- for each of 3 animals
- Time point:
- other: 24;48;72h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (24h exposure)
- Basis:
- mean
- Remarks:
- for each of 3 animals
- Time point:
- other: 24;48;72h
- Score:
- 2.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- chemosis score
- Remarks:
- (24h exposure)
- Basis:
- mean
- Remarks:
- for each of 3 animals
- Time point:
- other: 24;48;72h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
Any other information on results incl. tables
As the erythema and edema scores resulting from the 4sec- and 30sec-exposure are less relevant for an assessment of the eye irritating property of the substance, the details are not reported here.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
