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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without detailed documentation (study written in swedish)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Details on test material:
- Name of test material (as cited in study report): cyclohexanol
- Analytical purity: 99%

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 + 3°C
- Humidity (%): 50 + 20 %
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Duration of treatment / exposure:
4 sek; 30sek; 24h
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
3
Details on study design:

SCORING SYSTEM:
Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
1.9
Max. score:
4
Reversibility:
fully reversible within: 10 days
Remarks on result:
other: Mean (24,48; 72h) scores of each animal: animal #1 = 1.7; animal #2 = 2; animal #3 = 2
Irritation parameter:
iris score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
0
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
conjunctivae score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
2.1
Max. score:
4
Reversibility:
fully reversible within: 10 days
Irritation parameter:
chemosis score
Remarks:
(24h exposure)
Basis:
mean
Remarks:
for each of 3 animals
Time point:
other: 24;48;72h
Score:
2.3
Max. score:
4
Reversibility:
fully reversible within: 10 days

Any other information on results incl. tables

As the erythema and edema scores resulting from the 4sec- and 30sec-exposure are less relevant for an assessment of the eye irritating property of the substance, the details are not reported here.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information