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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(Inhalation hazard test)
Deviations:
yes
Remarks:
(only 6 hours of exposure, only 6 animals of one sex)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of cyclohexanol and cyclohexanone
EC Number:
906-627-4
Molecular formula:
Unspecified
IUPAC Name:
Reaction mass of cyclohexanol and cyclohexanone

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 260 g

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 70

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 35 l
Duration of exposure:
6 h
Concentrations:
6.6 mg/l
No. of animals per sex per dose:
6 males
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 6.6 mg/L air
Exp. duration:
6 h
Remarks on result:
other: no mortality occurred
Mortality:
No animals died
Clinical signs:
other: No toxic signs
Body weight:
Day 7: 330 g
Day 14: 390 g
Gross pathology:
Viscera appeared normal

Applicant's summary and conclusion