Registration Dossier
Registration Dossier
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EC number: 247-781-6 | CAS number: 26544-38-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No information on method used. Precedes establishment of guidelines and GLP
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No internationally harmonized guideline available in 1969. Data obtained froma reliable textbook of toxicology. Practical handling experience has not resulted in the questioning of the overall accuracy of this data.
- GLP compliance:
- no
- Test type:
- other: standard method at the time
Test material
- Reference substance name:
- Dihydro-3-(tetrapropenyl)furan-2,5-dione
- EC Number:
- 247-781-6
- EC Name:
- Dihydro-3-(tetrapropenyl)furan-2,5-dione
- Cas Number:
- 26544-38-7
- Molecular formula:
- C16H26O3
- IUPAC Name:
- 3-dodecenyl dihydrofuran-2,5-dione
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on dermal exposure:
- no data provided
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- > 6 200 - < 7 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The publication states that, although TPSA is not readily absorbed through the skin, the percutaneous lethal dose ranges from 6.2 to 7.5 grams/kg in rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal lethal dose of Tetrapropenyl succinic anhydride (TPSA) in rabbits was reported to be 6200 to 7500 mg/kg. The substance is not classified.
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