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Environmental fate & pathways

Hydrolysis

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Description of key information

The substance undergoes rapid hydrolysis at ambient temperatures and environmental pH levels.

Key value for chemical safety assessment

Half-life for hydrolysis:
21 min
at the temperature of:
25 °C

Additional information

A full Tier 1 and Tier 2 hydrolysis study was performed on TPSA according to OECD 111 guidelines. TPSA rapidly hydrolyzed at 50 ºC in the Tier 1 test. TPSA was found to be hydrolytically unstable at pH 4, 7 and 9 at temperatures of 15, 25 and 35 ºC. At 25 ºC, the calculated half-life (DT50) was 33 minutes at pH 4, 21 minutes at pH 7 and 1.3 minutes at pH 9. Aqueous abiotic hydrolysis is expected to contribute significantly to the degradation of TPSA under conditions associated with typical use and exposure.