Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-873-2 | CAS number: 6018-92-4
Endpoint summary
Administrative data
Description of key information
Oral:
LD50 cut-off = 500 mg/kg bw nickel hydrogencitrate
Dermal:
LD50 > 2000 mg/kg bw nickel hydrogencitrate
Key value for chemical safety assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
Oral
The oral acute toxicity study has been performed according to OECD guideline 423. First, groups of 6 female Sprague Dawley rats received a single oral dose of 2000 mg/kg bw nickel hydrogencitrate. All animals died within 72 hours after dosing. Mortalities were preceded by a decrease in spontaneous activity associated with partial ptosis, piloerection and bradypnea as well as a decrease in muscle tone and righting reflex. Furthermore, increased lachrymation was observed. In a second step, 6 female rats of the same strain were dosed with 300 mg/kg bw nickel hydrogencitrate. No animal died. At this dose level, there were no effects related to treatment. The LD50 cut-off was determined as 500 mg/kg bw nickel hydrogencitrate.
Inhalation
No reliable acute study public available.
Dermal
For the dermal route, a study according to OECD guideline 402 has been performed with nickel hydrogencitrate in 5 Sprague Dawley rats of each sex at a single dose of 2000 mg/kg bw. No mortality occured. There were no treatment-related effects. Therefore, the LD50 was determined as higher than 2000 mg/kg bw.
Remark:
Nickel hydrogencitrate and Trinickel dicitrate are comparable: Since citric acid is a multifunctional acid, at different pH values various intermediate ions like citrate, hydrogencitrate and dihydrogencitrate are formed.
Justification for classification or non-classification
Based on the available data, the substance Trinickel dicitrate needs to be cassified:
Oral
EU: R22 Harmful if swallowed.
CLP: Category 4
Inhalation:
There is conclusive data available which is not sufficient for classification.
Dermal
There is conclusive data available which is not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
