Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-873-2 | CAS number: 6018-92-4
Endpoint summary
Administrative data
Description of key information
In the performed in vitro tests, the test substance nickel hydrogencitrate did neither have skin irritation nor eye irritation potential.
Key value for chemical safety assessment
Additional information
Two in vitro test were performed in order to assess the irritation potential of nickel hydrogencitrate:
Skin
The skin irritation potential of nickel hydrogencitrate was tested according to the draft OECD guideline "In vitro skin irritation: human skin model test", dated December 2007. The administration of 25 mg of the test substance to the human skin model EpiDermTMdid not cause effects, e. g. loss of viability, suggesting irritation potential.
Eye
The in vitro HET-CAM test following the ICCVAM test method (dated November 2006) was performed to evaluate the irritation potential of nickel hydrogencitrate. The application of 300 µL of the test substance on the chorioallantoic membrane (CAM) of incubated chicken eggs did not cause effects related to irritation, e. g. haemorrhage, lysis or coagulation, on the CAM.
Based on the results of the in vitro studies, it is predicted that the test substance nickel hydrogencitrate is not irritating to the skin and the eye in vivo.
Remark:
Nickel hydrogencitrate and Trinickel dicitrate are comparable: Since citric acid is a multifunctional acid, at different pH values various intermediate ions like citrate, hydrogencitrate and dihydrogencitrate are formed.
Justification for classification or non-classification
Skin
There is conclusive data available which is not sufficient for classification.
Eye
There is conclusive data available which is not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
