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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

For long-term toxicity in fish, the key study is an early-stage toxicity in Oryzias latipes with a 41d NOEC for growth reported as 0.049 mg/L based on mean measured concentrations.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.049 mg/L

Additional information

The key study for long term effects is based on an Early-life stage: reproduction, (sub) lethal effects in Oryzias latipes completed in 2001 following the OECD Test Guideline 210 with a reported NOEC based on mean of measured concentrations of 0.28 mg/L. Concentrations of PAP maintained between 55 and 64% depending on the nominal concentration. One supporting study was included with klimisch of 1, Prolonged Toxicity Study in Oryzias latipes at 14 days according to OECD 204, with a reported LC50 of > 0.788 mg/L. Values based on mean measured concentrations calculated directly from data in the study report.