Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Endpoint summary
Administrative data
Description of key information
Accidental occupational exposure to pyridine by workers shows that the major adverse effects are generalized intoxication. Naturally-occurring pyridine can be consumed as a component of foods and flavours, and can be inhaled as a component of cigarette smoke.
Additional information
Accidental occupational exposure to pyridine by workers shows that the major adverse effects are generalized intoxication. Ingestion of pyridine may cause central nervous system depression, irritation of skin and respiratory tract. Large doses may produce GI disturbances, kidney and liver damage. Inhalation of pyridine may cause central nervous system depression. Pyridine was used clinically in the past as a treatment for epilepsy. Treatment with 1.85 to 2.46 ml of pyridine orally caused mild anorexia, nausea, fatigue, & depression. Many modern pharmaceuticals are derivatives of pyridine and may generate pyridine-based metabolites. Pyridine is a naturally-occuring component of foods and intentionally-added flavorings, and a component of cigarette smoke.
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