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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline study, prior to establishment of GLP. Data are reliable but study lacks details.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyridine
EC Number:
203-809-9
EC Name:
Pyridine
Cas Number:
110-86-1
Molecular formula:
C5H5N
IUPAC Name:
pyridine

Test animals

Species:
rabbit
Strain:
New Zealand White

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
500, 1000 or 2000 mg/kg
No. of animals per sex per dose:
2 per dose group
Control animals:
not specified
Details on study design:
14 day observation period.
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 000 - < 2 000 mg/kg bw
Based on:
test mat.
Mortality:
500 mg/kg = 0/2
1000 mg/kg = 0/2
2000 mg/kg = 2/2. The animals in the 2000 mg/kg dose group died by day 1 post exposure.
Clinical signs:
other: Lethargy and an initial loss of weight were observed in all animals. Topical skin effect at all levels was a severe chemical burn.
Gross pathology:
Gross pathological examination of the surviving rabbits revealed no compound-related changes.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information 1000 mg/kg < LD50 < 2000 mg/kg Criteria used for interpretation of results: EU
Conclusions:
Pyridine was testing in albino rabbits in an acute dermal toxicity test at 500, 1000 and 2000 mg/kg bw . No deaths occurred at 1000 mg/kg or lower, but all animals died at 2000 mg/kg bw. The LD50 is between 1000 and 2000 mg/kg bw.