Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Waiver: Studies on effects on birds do not need to be conducted as secondary poisoning is not of concern. Pyridine has a log Kow of 0.64 and a BCF of 3.162; each value is below the threshold of concern for secondary poisoning.
Key value for chemical safety assessment
Additional information
In accordance with Regulation (EC) No.1907/2006, Annex X, Section 9.6.1, Column 2, studies on the effects of a substance upon birds should be conducted only if other data, including mammalian toxicity data, are inadequate for the evaluation secondary poisoning risks to predators following chronic exposure to a substance via the fish and earthworm food chains ((Section R.7.10.14,Guidance on information requirements and chemical safety assessment, Chapter R.7C, Endpoint-specific guidance, May 2008). An acceptable database of repeat dose oral toxicity data is available for mammals (i.e., rodents). In addition, evaluation of upper trophic level exposures (secondary poisoning) is not of concern. "Secondary poisoning" refers to the toxic effects in the higher members of a food chain that result from ingestion of organisms from lower trophic levels that contain accumulated substances (and/or related metabolites). To be evaluated for secondary poisoning, the chemical must have a log Kow≥ 3 or a BCF ≥ 100; and no mitigating property such as biodegradability or hydrolysis (half life less than 12 hours). Since the log Kowfor pyridine is 0.64 (based on the measured value reported by Verschuren, 1983), and the BCF for pyridine is 3.162 (as predicted by the BCFBAF v3.00 model in EPI-Suite, based on a log Kowof 0.64), then neither of the first two screening criteria are satisfied for pyridine(Section R.16.4.3.5, Chapter R.16, Environmental exposure estimation, Guidance on information requirements and chemical safety assessment, ECHA, May 2008). Therefore, pyridine may be waived with respect to the evaluation of secondary poisoning and the derivation of a PNECoralfor wildlife exposures, including the food chain exposures of birds (Section R.10.8.1, Chapter R.10, Characterisation of dose[concentration]-response for environment, of Guidance on information requirements and chemical safety assessment, ECHA, May 2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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