Registration Dossier

Administrative data

Description of key information

No skin or eye irritation data are available. However, in accordance with Column 2 of REACH Annex VIII, the in vivo skin and eye irritation studies (required in Sections 8.1.1 and 8.1.2) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Trichloro(3 -chloropropyl)silane hydrolyses rapidly (half-life <1 minute at pH 7) in contact with water and moist air, generating 3 moles of hydrogen chloride (HCl) per mole of parent material. HCl is highly corrosive and is classified as R35/Skin Corr. 1A in Annex VI of Regulation 1272/2008. On this basis, it can be predicted that the registered substance is also highly corrosive and it is not appopriate to carry out further testing on the grounds of animal welfare. This is consistent with measured in vivo data for other chlorosilanes.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

Trichloro(3 -chloropropyl)silane is labelled 'R35 Causes severe burns' according to the criteria of EU Directive 67/548/EEC, and 'Skin Corr. 1A' under Regulation 1272/2008. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes. There are no specific data for respiratory irritation. However, for consistency with other similar chlorosilane materials, the test substance is labelled as 'R37 Irritating to respiratory system', and the hazard statement 'EUH071 Corrosive to the respiratory tract' is proposed, based on effects observed in acute inhalation studies with these materials.