Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via inhalation route
Dose descriptor:
NOAEC
867 mg/m³
Additional information

There are no reproductive toxicity data on trichloro(3 -chloropropyl)silane or its hydrolysis product, 3 -chloropropylsilanetriol, so good quality data for the related substance trimethoxy(3 -chloropropyl)silane have been used to assess the reproductive toxicity of trichloro(3 -chloropropyl)silane.

Trichloro(3 -chloropropyl)silane hydrolyses rapidly in contact with water (half-life <1 minute at pH 7), generating HCl and 3 -chloropropylsilanetriol. Trimethoxy(3 -chloropropyl)silane (CAS 2530 -87 -2) hydrolyses more slowly at pH 7 (half-life ca. 1 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and 3 -chloropropylsilanetriol. Both parent materials therefore generate a common silanol hydrolysis product.

For the inhalation route, the hydrolysis rate of trimethoxy(3 -chloropropyl)silane in the respiratory tract and lungs is unknown, but is likely to be slower than that of the corresponding chlorosilane. For trichloro(3 -chloropropyl)silane, the species absorbed following inhalation exposure are mainly hydrolysis products, whereas for the trimethoxy substance, absorption of the parent substance may be more significant. Trimethoxy(3 -chloropropyl)silane has a higher log Kowvalue (1.96), than the silanol (-1.13) therefore the proportion of inhaled material which is systemically absorbed is likely to be greater for the trimethoy analogue than for the chlorosilane. Nevertheless, in the absence of other data, the inhalatory NOAEC for trimethoxy (3 -chloropropyl)silane is considered to represent a reasonable worst-case for read-across to trichloro (3 -chloropropyl)silane.


Short description of key information:
No reproductive toxicity data are available for trichloro(3-chloropropyl)silane, therefore good quality data for the related substance trimethoxy(3-chloropropyl)silane have been read-across.
Trimethoxy(3-chloropropyl)silane was tested in an inhalation OECD 422 study, whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of adverse effects on reproduction. Therefore based on these results the NOAEC was established to be at least 100 ppm (867 mg/m3).

Effects on developmental toxicity

Description of key information
No developmental toxicity data are available for trichloro(3-chloropropyl)silane, therefore good quality data for the related substance trimethoxy(3-chloropropyl)silane have been read-across.
Trimethoxy(3-chloropropyl)silane was tested in an inhalation OECD 422 study, whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of adverse effects on development. Therefore based on these results the NOAEC was established to be at least 100 ppm (867 mg/m3).
Effect on developmental toxicity: via inhalation route
Dose descriptor:
NOAEC
867 mg/m³
Additional information

There are no developmental toxicity data on trichloro(3 -chloropropyl)silane or its hydrolysis product, 3 -chloropropylsilanetriol, so good quality data for the related substance trimethoxy(3 -chloropropyl)silane have been used to assess the developmental toxicity of trichloro(3 -chloropropyl)silane.

Trichloro(3 -chloropropyl)silane hydrolyses rapidly in contact with water (half-life <1 minute at pH 7), generating HCl and 3 -chloropropylsilanetriol. Trimethoxy(3 -chloropropyl)silane (CAS 2530 -87 -2) hydrolyses more slowly at pH 7 (half-life ca. 1 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other methoxysilanes. The relevant hydrolysis products are methanol and 3 -chloropropylsilanetriol. Both parent materials therefore generate a common silanol hydrolysis product.

For the inhalation route, the hydrolysis rate of trimethoxy(3 -chloropropyl)silane in the respiratory tract and lungs is unknown, but is likely to be slower than that of the corresponding chlorosilane. For trichloro(3 -chloropropyl)silane, the species absorbed following inhalation exposure are mainly hydrolysis products, whereas for the trimethoxy substance, absorption of the parent substance may be more significant. Trimethoxy(3 -chloropropyl)silane has a higher log Kowvalue (1.96), than the silanol (-1.13) therefore the proportion of inhaled material which is systemically absorbed is likely to be greater for the trimethoy analogue than for the chlorosilane. Nevertheless, in the absence of other data, the inhalatory NOAEC for trimethoxy (3 -chloropropyl)silane is considered to represent a reasonable worst-case for read-across to trichloro (3 -chloropropyl)silane.

Justification for classification or non-classification

There are no data to suggest that trichloro(3 -chloropropyl)silane should be classified for reproductive or developmental toxicity.