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Long-term toxicity to aquatic invertebrates

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Description of key information

NOEC (21d) = 0.2 mg/L

Key value for chemical safety assessment

Additional information

No study is available on the long-term toxicity of azelaic acid to aquatic invertebrates. However, a study investigating the long-term toxicity of decanoic acid is available and used as read across based on a category approach. Both substances are structurally and compositionally related. Due to an increasing toxicity with increasing chain length from octanoic acid (C8) to lauric acid (C12) for fish, the study for decanoic acid (C10) represents a worst case for azelaic acid (C9), probably overestimating the toxicity for azelaic acid.

In this study (Ministry of the Environment of Japan, 1999) with Daphnia magna conducted according to OECD 211 a NOEC of 0.2 mg/L (nominal) was determined.