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Short-term toxicity to fish

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Description of key information

LC50 (96h) > 16 mg/L (meas. geom. mean)

Key value for chemical safety assessment

Additional information

No study is available on the short-term toxicity of azelaic acid to fish. However, a study investigating the short-term toxicity to fish of decanoic acid is available and used as read across based on a category approach. Both substances are structurally and compositionally related. Due to an increasing toxicity with increasing chain length from octanoic acid (C8) to lauric acid (C12) for fish, the study for decanoic acid (C10) represents a worst case for azelaic acid (C9), probably overestimating the toxicity for azelaic acid.

In this study (Ministry of the Environment of Japan, 1999) with Oryzias latipes conducted according to OECD 203 an LC50 >16 mg/L (meas. geom. mean) was determined. No mortality was observed in the range of the tested concentration (16 mg/L meas. geom. mean).