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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
Acute oral toxicity study with rats
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Decanoic acid
EC Number:
206-376-4
EC Name:
Decanoic acid
Cas Number:
334-48-5
IUPAC Name:
decanoic acid
Details on test material:
- Name of test material (as cited in study report): UDL-910
- Composition of test material, percentage of components: no further data given
- Analytical purity: no information given

Test animals

Species:
rat
Strain:
other: COX-SD
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 187 - 322 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
ethanol
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 5%
Doses:
10000, 14000, 16800, 19600 and 25000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
15 800 mg/kg bw
Based on:
test mat.
95% CL:
14 110 - 17 700
Mortality:
10000 mg/kg bw: no mortality
14000 mg/kg bw: 2/5males
16800 mg/kg bw: 3/5 males and 3/5 females
19600 mg/kg bw: 5/5 males and 5/5 females
25000 mg/kg bw: 5/5 males and 5/5 females
Clinical signs:
10000 mg/kg bw: decrease of motor activity, accelerated breathing, loss of righting reflex and proneness for 4hours
14000 mg/kg bw: decrease of motor activity for 24 hours, accelerated breathing, loss of righting and corneal reflex and proneness for 4 hours
16800 mg/kg bw: decrease of motor activity, accelerated breathing, loss of righting and corneal reflex and proneness for 4 hours
19600 mg/kg bw: decrease of motor activity, loss of righting and corneal reflex and proneness for 4 hours
25000 mg/kg bw: decrease of motor activity, loss of righting and corneal reflex and proneness for 4 hours
Body weight:
Average body weights (g) on days 0 / 14:
10000 mg/kg bw: 235 / 287
14000 mg/kg bw: 247 / 295
16800 mg/kg bw: 272 / 295
19600 mg/kg bw: 240 / -
25000 mg/kg bw: 230 / -
Gross pathology:
Surviving animals showed moderate congestion of the kidneys and adrenal glands with proliferation of the mucosal tissue of the stomach. At doses above 19600 mg/kg bw also hemolytic lesions in the stomach were observed.

Applicant's summary and conclusion

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