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EC number: 211-750-5 | CAS number: 693-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study with limited but sufficient documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- The Fate of [14C]Thiodipropionates in Rats
- Author:
- Reynolds, R.C., Astill, B. D., and Fassett, D.W.
- Year:
- 1 974
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 28, 133-141 (1974)
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- yes
- Remarks:
- limited reporting details
- GLP compliance:
- no
Test material
- Reference substance name:
- Didodecyl 3,3'-thiodipropionate
- EC Number:
- 204-614-1
- EC Name:
- Didodecyl 3,3'-thiodipropionate
- Cas Number:
- 123-28-4
- Molecular formula:
- C30H58O4S
- IUPAC Name:
- didodecyl 3,3'-sulfanediyldipropanoate
- Details on test material:
- Carboxy 14C-labeled didodecyl thiodipropionate ([14C]DDTDP), specific activity 60 microCi/mmol, was purified (99.2% by chromatography) by recrystallization from aqueous acetone.
[14]Thiodipropionate, specific activity 1.71 mCi/mmol
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 215 - 325g
- Fasting period before study:
- Housing: in glass metabolism cages, for collection of urine, feces and exhaled carbon dioxide
- Individual metabolism cages: yes
- Diet: animals were starved prior to dosing
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Route of administration:
- other: oral in feed, and oral by gavage
- Vehicle:
- other: see below
- Details on exposure:
- In some experiments the dose was incorporated into powdered Purina Lab Chow (20 mesh), homogenized hen’s egg (1 egg/50 g) and water to a stiff paste which was heated and formed into sticks (10-12 g).
In other experiments, didodecylthiodipropionate was dissolved in corn oil and applied by gavage.
[14]Thiodipropionate was dissolved in ethanol: water 1:1 if given by gavage. - Duration and frequency of treatment / exposure:
- single treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Thiodipropionic acid: 3.1 mg/kg bw (gavage), 650 mg/kg bw (gavage), 572 mg/kg bw (gavage), 551 mg/kg bw (gavage) and 241 mg/kg bw (feed)
Didodecylthiodipropionic acid: 107 and 208 mg/kg bw (gavage), 166 mg/kg bw (feed)
- No. of animals per sex per dose / concentration:
- 1
- Control animals:
- no
- Positive control reference chemical:
- not required
- Details on study design:
- Thin-layer and paper chromatography of urine for metabolite detection was unsuccessful because of the tendency of dithiopropionic acid to migrate as more than one spot with most solvent systems. In consequence, reverse isotope dilution studies were carried out with untreated and hydrolyzed urines to assay elimination of free and combined [14C]-ditihiopropionic acid.
- Details on dosing and sampling:
- For feed application, rats were kept in the metabolism cages for 34 days.
For gavage application, rats were kept in the metabolism cage for 4 days or 8 days.
Urines and CO2 absorbers were processed daily. Liver, kidneys, brain, heart, lungs, whole gastrointestinal tracts and fat samples were removed at sacrifice and frozen with carcasses until assayed.
Metabolites were isolated by consecutive continuous ether extractions of urine at pH >9 and <2. Glucuronidase treatment was performed to identify glucuronic acid conjugates. - Statistics:
- not applicable
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Complete absorption of both thiodipropionic acid and Didodecyl thiopropionic acid
- Type:
- excretion
- Results:
- as acid labile conjugate of thiodipropionic acid or free thiodipropionic acid, >90% in urine, less than 5% as carbon dioxide
- Type:
- distribution
- Results:
- Low amounts of [14C]-Didodecylthiodipropionate is found in fat tissues at the last sacrifice on day 34.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The didodeylester is completely absorbed when fed at a single dose of 210 mg/kg bw. Thiodipropionic acid is completely absorbed when fed at a single doses of 3 - 6 or 650 mg/kg bw.
- Details on distribution in tissues:
- Distribution in tissues was close to normal values except that for the didoceylester, the value of radioactivity in the fat were elevated at 4 days after dosing and remained so at 8 and 34 days. Data is given for liver, kidney, brain, heart, lung, gastrointestinal tract, fat and carcass.
- Details on excretion:
- Urinary elimination accounts for more than 90% of the dose. Elimination in carbon dioxide accounts for ca 5% of the dose. More than 90% of the dose is eliminated within the first 24h. This data is given as a graph. Didodecyl thiodipropionate appears to be almost completely eliminated within 3 days.
Acid hydrolysis of urine samples afforded high rates of recovery approaching 100% of the urinary radioactivity after feeding.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Dithiopropionic acid is recovered as a acid-labile conjugate if given at doses of 3 - 6 mg/kg bw. At 650 mg/kg bw, the major fraction is recovered in the non-conjugated form. The acid-labile conjugate is not or only to a small fraction a glucuronidate. Further identification was not performed.
Any other information on results incl. tables
Table 1: Cumulative elimination in the rat after gavage and feed application
Compound | Rat no. | dose [mg/kg bw] | dose [μCi] | gavage/feed | time [days] | Elimination | |||
urine | carbon dioxide | feces | total | ||||||
Thiodipropionic acid | 1 | 3.1 | 9.3 | gavage | 4 | 90.10% | 3.10% | 0.50% | 93.60% |
2 | 650 | 9 | gavage | 4 | 78.10% | 8.20% | 0.50% | 86.80% | |
3 | 572 | 9.3 | gavage | 4 | 84.50% | 2.80% | 0.90% | 88.40% | |
4 | 551 | 8.9 | gavage | 8 | 88.50% | 7.20% | 0.20% | 95.90% | |
5 | 241 | 8.2 | feed | 34 | 87.40% | 3.30% | 0.10% | 90.70% | |
Didodecyl thiodipropionate | 1 | 107 | 3.3 | gavage | 4 | 84.60% | 2.90% | 3.50% | 90.90% |
2 | 208 | 6.6 | gavage | 8 | 88.50% | 3.90% | 1.80% | 94.40% | |
3 | 166 | 4 | feed | 34 | 86.10% | 3.20% | 0.10% | 89.40% |
Applicant's summary and conclusion
- Conclusions:
- low bioaccumulation potential based on study results
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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