Registration Dossier
Registration Dossier
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EC number: 211-750-5 | CAS number: 693-36-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Experimental data is available for didodecyl thiodipropionate (Reynolds 1974). The read-across substance has a C12 fatty acid ester with thiodipropionic acid instead of a C18 fatty acid ester. It is expected to become absorbed more efficiently since it is of lower molecular weight, but both substances have a structural similarity to fats and no differences in metabolism are expected.
After gavage or feed application, didodecyl thiodipropionate was completely absorbed. As indicated by 14C-label in the thiodipropionate, more than 90% of the dose was eliminated in the urine within 24h after dosing. At low doses, an acid labile conjugate was detected in urine, whereas at high doses, a major fraction was the free thiodipropionic acid. Distribution in tissue was only investigated at high doses: A small fraction of the radioactive dose still remained in the fat tissue at the last time point of 34 days after dosing. From the data it is concluded that the substance is efficiently absorbed and undergoes rapid ester hydrolysis. At low doses, ester hydrolysis is expected to be complete so that no incorporation in fat tissue is expected. At high doses, it is possible that incorporation in fat occurs prior to hydrolysis. No hazard for bioaccumulation is identified.
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