Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-629-0 | CAS number: 108-91-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- other: comprehensive reviews
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Cyclohexylamine
- Author:
- German MAK Commission
- Year:
- 2 006
- Bibliographic source:
- MAK Value Documentation, Vol22 DFG; WILEY Verlag, Weinheim
- Reference Type:
- review article or handbook
- Title:
- Cyclohexylamine. Health basedreassessment of administrative occupational exposure limits
- Author:
- NL HealthCouncil
- Year:
- 2 001
- Bibliographic source:
- Health Council of the Netherlands, The Hague
- Reference Type:
- review article or handbook
- Title:
- Toxicological aspects of cyclamate and cycvlohexylamine
- Author:
- Bopp BA, Sonders RC, Keterson JW
- Year:
- 1 986
- Bibliographic source:
- CRC Crit. Rev. Toxicol. 16, 213-306
Materials and methods
- Principles of method if other than guideline:
- Comprehensive reviews
Results and discussion
Any other information on results incl. tables
There are many studies available that investigate acute toxicity after parental exposure. Based on all available data the authors discuss the following LD50 values:
LD50 (i.p.)approx. 350 mg/kg for rats and approx. 619 mg/kg for mice; LD50 (s.c.) for mice approx. 1150 mg/kg and LD50(i.v.) for dogs approx. 200 mg/kg
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
