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EC number: 203-629-0 | CAS number: 108-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically aceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- Single oral application of different doses to rats and observation for 7 days for symptoms and mortality; determination of LD50 according to Litchfield and Wicoxon
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- male Wistar rats with body weights ranging between 150 and 200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2% of the body weight
- Doses:
- 25, 50, 100, 250, 300, 350, 500, 600, 750, 1000 mg/kg bw
- No. of animals per sex per dose:
- 15
- Control animals:
- no
- Details on study design:
- Single oral application of different doses to male rats and observation for 7 days for symptoms and mortality; determination of LD50 according to Litchfield and Wicoxon
- Statistics:
- determination of LD50 according to Litchfield and Wicoxon
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 432 mg/kg bw
- 95% CL:
- >= 376 - <= 496
- Sex:
- male
- Dose descriptor:
- other: NOAEL
- Effect level:
- ca. 25 mg/kg bw
- Mortality:
- ---25, 50, 100, 250 mg/kg bw : no mortality
---one day after application
300 mg/kg bw: 2/15
350 mg/kg bw: 4/15
500 mg/kg bw 9/15
600 mg/kg bw: 13/15
750, 1000 mg/kg bw 15/15 - Clinical signs:
- other: 25 mg/kg bw: no clinical signs, 50, 100 mg/kg bw start 1 hour post application and end within 2 days post application 250, 300, 350, 500, 600 mg/kg bw start within 30 min post applicatio and end within 5 days after application 750, 1000 mg/kg bw start wi
- Gross pathology:
- not done
- Other findings:
- no further data
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Executive summary:
Single oral application of 25, 50, 100, 250, 300, 350, 500, 600, 750, 1000 mg/kg bw Cyclohexylamindiluted in Lutrol yielded a LD50 value of 432 mg/kg bw . 25 mg/kg bw was tolerated without clinical signs and without mortality (NOAEL) whereas at 750 mg/kg bw and at 1000 mg/kg bw all rats died within few minutes post application (Bayer AG 1968).
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