Registration Dossier
Registration Dossier
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EC number: 202-684-8 | CAS number: 98-59-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case study
- Adequacy of study:
- supporting study
- Study period:
- 1995
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Short publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational contact dermatitis from tosyl chloride in a chemist
- Author:
- Watsky KL, Reynolds K, Berube D, Bayer FJ
- Year:
- 1 995
- Bibliographic source:
- Contact Dermatitis. 1993 Oct;29(4):211-2.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- Patch testing with tosyl chloride (0.05% and 1% in ethanol)
Test material
- Reference substance name:
- Tosyl chloride
- EC Number:
- 202-684-8
- EC Name:
- Tosyl chloride
- Cas Number:
- 98-59-9
- Molecular formula:
- C7H7ClO2S
- IUPAC Name:
- 4-methylbenzenesulfonyl chloride
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- A case of dermal sensitisation to Tosyl chloride in a chemist is reported.
- Executive summary:
Case Report:
A 26-year-old female Indian chemist complained of a several-year history of hand dermatitis dating back to graduate school. While working in the laboratories of a major pharmaceutical company, she had multiple outbreaks of dermatitis which she related to the use of tosyl chloride. She was able to control her condition by using nitrile gloves, but presented for further evaluation and patch testing. None of the other members of her laboratory had dermatitis. The patient had a history of nickel allergy and mild seasonal allergies. There was a family history of allergies to pollen.
Patch testing with the North American standard series and tosyl chloride (0.05% and 1% eth.) gave the following reactions.
observation day
D2
D3
D7
cobalt chloride
+
+
epoxy resin
+
++
nickel sulfate
++
+++
tosyl chloride 0.05%
?+
+
Tosyl chloride 1%
+
Because the reaction to tosyl chloride might have been irritant, due to conversion to p-toluenesulfonic and hydrochloric acids. patch testing was performed at the workplace. None of 3 co-workers reacted to tosyI chloride (0.05% and I% eth.)
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