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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Toxicity of methyl 5-nitrohydrogen.isophthalate in any of the routes have to been distinctly observed.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
1 387.52 mg/kg bw

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
not specified
Sex:
male/female
Doses:
>16 gm/kg
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 other: gm/kg
Remarks on result:
other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
Mortality:
50 percent kill
Clinical signs:
other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
Conclusions:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
Executive summary:

The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
16 000 mg/kg bw

Additional information

Acute oral toxicity:

Oral toxicity (LD50) Rat for 2-(2-ethoxyethoxy) ethyl acetate was examined at dose concentration of 11000 mg/kg of body weight. This value suggests that the chemical does not exhibit acute toxicity through the oral route.

Acute inhalation toxicity:

A reliable handbook source Patty's Toxicology indicated that Rats and guinea pigs exposed to essentially saturated atmospheres of test substance at room temperature for 8 h all survived, although injury to the lungs and kidneys was observed at necropsy.

Acute dermal toxicity:

The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.

Justification for classification or non-classification

The LD 50 values for 2-(2-ethoxyethoxy) ethyl acetate suggest that the substance will not be classified in any of the acute toxicity categories as per the C & L criteria set by EU.