Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-793-6 | CAS number: 1955-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Toxicity of methyl 5-nitrohydrogen.isophthalate in any of the routes have to been distinctly observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 387.52 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Doses:
- >16 gm/kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 other: gm/kg
- Remarks on result:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
- Mortality:
- 50 percent kill
- Clinical signs:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
- Conclusions:
- The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
- Executive summary:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 16 000 mg/kg bw
Additional information
Acute oral toxicity:
Oral toxicity (LD50) Rat for 2-(2-ethoxyethoxy) ethyl acetate was examined at dose concentration of 11000 mg/kg of body weight. This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Acute inhalation toxicity:
A reliable handbook source Patty's Toxicology indicated that Rats and guinea pigs exposed to essentially saturated atmospheres of test substance at room temperature for 8 h all survived, although injury to the lungs and kidneys was observed at necropsy.
Acute dermal toxicity:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
Justification for classification or non-classification
The LD 50 values for 2-(2-ethoxyethoxy) ethyl acetate suggest that the substance will not be classified in any of the acute toxicity categories as per the C & L criteria set by EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
