Registration Dossier
Registration Dossier
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EC number: 217-793-6 | CAS number: 1955-46-0
Endpoint summary
Administrative data
Description of key information
Toxicity of methyl 5-nitrohydrogen.isophthalate in any of the routes have to been distinctly observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 387.52 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Doses:
- >16 gm/kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 other: gm/kg
- Remarks on result:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
- Mortality:
- 50 percent kill
- Clinical signs:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
- Conclusions:
- The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
- Executive summary:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 16 000 mg/kg bw
Additional information
Acute oral toxicity:
Oral toxicity (LD50) Rat for 2-(2-ethoxyethoxy) ethyl acetate was examined at dose concentration of 11000 mg/kg of body weight. This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Acute inhalation toxicity:
A reliable handbook source Patty's Toxicology indicated that Rats and guinea pigs exposed to essentially saturated atmospheres of test substance at room temperature for 8 h all survived, although injury to the lungs and kidneys was observed at necropsy.
Acute dermal toxicity:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
Justification for classification or non-classification
The LD 50 values for 2-(2-ethoxyethoxy) ethyl acetate suggest that the substance will not be classified in any of the acute toxicity categories as per the C & L criteria set by EU.
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