Registration Dossier
Registration Dossier
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EC number: 217-793-6 | CAS number: 1955-46-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS doc no: BZ8800000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 27,265,1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 5-nitrohydrogen.isophthalate
- EC Number:
- 217-793-6
- EC Name:
- Methyl 5-nitrohydrogen.isophthalate
- Cas Number:
- 1955-46-0
- Molecular formula:
- C9H7NO6
- IUPAC Name:
- 3-(methoxycarbonyl)-5-nitrobenzoic acid
- Details on test material:
- SMILES:C(=O)(O)c1cc(C(=O)OC)cc(N(=O)=O)c1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Doses:
- >16 gm/kg
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 other: gm/kg
- Remarks on result:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
- Mortality:
- 50 percent kill
- Clinical signs:
- other: Toxic effects: Liver - fatty liver degeneration Kidney/Ureter/Bladder - other changes.
Applicant's summary and conclusion
- Conclusions:
- The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
- Executive summary:
The LD50 for chemical 3-(methoxycarbonyl)-5-nitrobenzoic acid was determined to be >16 gm/kg when exposed to male/female rats orally.
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