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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: EU Method A.7 (Fat Solubility)
Deviations:
no
Remarks:
The study was conducted according to the guidelines in effect at the time of study conduct.
GLP compliance:
yes
Medium:
standard fat
Solubility:
241 mg/100 g solvent
Temp.:
37 °C
Test substance stable:
not determined
Conclusions:
The fat solubility of the test substance has been determined as 241 mg/100 g Standard Fat at 37ºC.
Executive summary:

The fat solubility of the test substance was determined in accordance with EEC Directive 67/548, Annex V, A7. Results contained in the report include calibration data, solubility results for each trial, and typical chromatorgams. Values of fat solubility were not corrected for test substance purity. Normally 3-hour and 24 -hour tests are performed. However, in the case of this test substance, longer stirring times were needed to achieve equilibration. Fat solubility was calculated as the mean result of the 24- and 64 -hour tests. The fat solubility was determined as 241 mg/100 g Standard Fat at 37ºC. The associated standard deviation of all tests was 26.8 mg/100 g Standard Fat with a coefficient of variation of 11.1%.

Description of key information

EU Method A.7

Key value for chemical safety assessment

Solubility in mg/100g standard fat:
241
At the temperature of:
37 °C

Additional information