Registration Dossier
Registration Dossier
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EC number: 219-397-9 | CAS number: 2431-50-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: original data not available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 478 (Genetic Toxicology: Rodent Dominant Lethal Test)
- GLP compliance:
- no
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- 2,3,4-trichlorobut-1-ene
- EC Number:
- 219-397-9
- EC Name:
- 2,3,4-trichlorobut-1-ene
- Cas Number:
- 2431-50-7
- Molecular formula:
- C4H5Cl3
- IUPAC Name:
- 2,3,4-trichlorobut-1-ene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 6h/d, 5d
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.018 mg/l (2.78 ppm)
Basis:
- No. of animals per sex per dose:
- no data
Examinations
- Tissues and cell types examined:
- no data
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Freetext:
No induction of dominant lethal mutations
Applicant's summary and conclusion
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