2,3,4-trichlorobut-1-ene

Toxicity to reproduction

Administrative data

Endpoint:

fertility, other

Remarks:

based on test type (migrated information)

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Original data not available

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Materials and methods

Principles of method if other than guideline:

Male Wistar rats were exposed to 0.018 mg/l (2.78 ppm) for 5 days. Food consumption, body weights, pregnancy rate, mean number of total and dead implants and preimplantation were observed.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,3,4-trichlorobut-1-ene

EC Number:

219-397-9

EC Name:

2,3,4-trichlorobut-1-ene

Cas Number:

2431-50-7

Molecular formula:

C4H5Cl3

IUPAC Name:

2,3,4-trichlorobut-1-ene

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Administration / exposure

Route of administration:

inhalation

Duration of treatment / exposure:

Exposure period: 5d

Frequency of treatment:

6h/d

Doses / concentrations

Remarks:

Doses / Concentrations:
0.018 mg/l (2.78 ppm)
Basis:

Control animals:

yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:

not specified

Any other information on results incl. tables

Freetext:
decreased food consumption and body weights during
exposure; pregnancy rate, mean number of total and dead
implants and preimplantation were not adversely affected