Registration Dossier
Registration Dossier
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EC number: 219-397-9 | CAS number: 2431-50-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original data not available
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- !SIDSP*
- Year:
- 1 993
- Bibliographic source:
- OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, 19, (1993)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Developmental toxicity and teratogenicity were analyzed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,4-trichlorobut-1-ene
- EC Number:
- 219-397-9
- EC Name:
- 2,3,4-trichlorobut-1-ene
- Cas Number:
- 2431-50-7
- Molecular formula:
- C4H5Cl3
- IUPAC Name:
- 2,3,4-trichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 1-Butene, 2,3,4-trichloro
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- no data
- Duration of treatment / exposure:
- 6th to 16th day of gestation
- Frequency of treatment:
- 6h/d
- Duration of test:
- 10 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.0007, 0.003, 0.017 mg/L (0, 0.1, 0.5, 2.5 ppm)
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- Post observation period: until 21st day of gestation
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
At 2.5 ppm: decreased food consumption and bodyweights
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 0.003 other: mg/L
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- LOAEC
- Effect level:
- 0.017 other: mg/L
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no data
Details on embryotoxic / teratogenic effects:
At 2.5 ppm: decreased foetal weight, no teratogenicity
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 0.003 other: mg/L
- Basis for effect level:
- other: teratogenicity
- Dose descriptor:
- LOAEC
- Effect level:
- 0.017 other: mg/L
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Freetext:
NOEL for maternal animals: 0.5 ppm
NOEL for offspring: 0.5 ppm
Maternal general toxicity: decreased food consumption and
bodyweights in the 2.5 ppm-group
Pregnancy and litter data: decreased foetal weight in the
2.5 ppm-group, no teratogenicity
Applicant's summary and conclusion
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