Registration Dossier
Registration Dossier
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EC number: 448-050-6 | CAS number: 444065-11-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h) > 0.01 mg/L (average exposure concentration) (ISO 8692)
Key value for chemical safety assessment
Additional information
A study determining the toxicity of 2-(4-tert-butylphenyl)-6-cyano-5-[bis(ethoxycarbonylmethyl)carbamoyloxy]-1 H-pyrrolo[1 ,2-b][1 ,2,4]triazole-7-carboxylic acid-2,6-di-tert-butyl-4-methyl-cyclohexyl ester
(UC-141) to algae is available (Bouwman, 2004). This test was conducted according to ISO Guideline 8692 under GLP conditions. Selenastrum capricornutum was exposed for 72 hours to a filtrate of a solution of the test substance prepared at 100 mg/L (nominal). Two additional replicates were included in the test set-up at 100 mg/L without algae. Analytical determinations after 0 and 24 hours in the test vessels containing algae proved that the test concentration after 24 hours was already below the limit of detection. However, concentrations in vessels without algae could be still determined at this time point (0.01 mg/L), indicating that adsorption to algae cells might have contributed to the decrease of test concentrations in the standard treatment group. No significant effects regarding biomass or growth rate were observed after 72 hours exposure to the test substance. Therefore, an EC50 value could not be determined and it is considered to be > 0.01 mg/L (mean measured concentration).
In conclusion, UC-141 was not acutely toxic to algae under the tested conditions.
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