1-vinylimidazole

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1953

Report date:

1953

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

Testing saturated vapour concentration

Principles of method if other than guideline:

Inhalation hazard test (rat):
This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile com-ponents of a test substance at the temperature chosen for vapor generation (usually 20°C). Young adult laboratory rats were purchased from a breeder. In general, the source and strain of the animals were not documented. 4 rats were exposed sequentially to the vapors, generated by bubbling 100 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 6 - 7 hours.
No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.
Group-wise documentation of clinical signs was performed over the 7- to 14- day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals.The clinical signs and findings were reported in summarized form. More details can usually be inferred as mentioned for the acute oral studies.
The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.

GLP compliance:

no

Remarks:

pre-GLP

Test type:

other: saturated vapour concentration

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-vinylimidazole

EC Number:

214-012-0

EC Name:

1-vinylimidazole

Cas Number:

1072-63-5

Molecular formula:

C5H6N2

IUPAC Name:

1-ethenyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): N-Vinylimidazol

Specific details on test material used for the study:

PSN I/261

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

> 6 - < 7 h

Remarks on duration:

5x 6-7 hours within 7 days

Concentrations:

- saturated vapour concentration: 0.6 - 2.3 mg/L (about 160 - 600 ppm)
- calculated: 0.0412*MG*VP = 0.0412*94.1 g/mol*0.38 hPa = 1.47 mg/L

No. of animals per sex per dose:

4 rats

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

1.47 mg/L air (nominal)

Based on:

test mat.

Mortality:

no mortality

Clinical signs:

other: no clinical symptoms

Other findings:

no adverse findings in urine and blood parameters