1-vinylimidazole

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1953

Report date:

1953

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Principles of method if other than guideline:

Method: BASF test: 50 µl of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed up to 24 days after treatment. Findings were recoded daily.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-vinylimidazole

EC Number:

214-012-0

EC Name:

1-vinylimidazole

Cas Number:

1072-63-5

Molecular formula:

C5H6N2

IUPAC Name:

1-ethenyl-1H-imidazole

Details on test material:

- Name of test material (as cited in study report): n-Vinylimidazol
no further data

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

water

Controls:

other: untreated eyes of the same animals

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.05-0.1 mL
- Concentration (if solution): undiluted and 10, 5, 1 and 0.1% aqueous solution

Duration of treatment / exposure:

single application

Observation period (in vivo):

up to 24 days

Number of animals or in vitro replicates:

2 for undiluted test substance, 1 per aqeous solution (10, 5, 1 and 0.1%)

Results and discussion

In vivo

Results

Irritation parameter:

other: severe redness of the conjunctivae, secretion of pus, bleeding of the conjunctivae, ciliary injection and severe oedema

Basis:

animal: 2 animals

Reversibility:

other: Corneal cloudiness was still reported at the end of the observation period (d24).

Remarks on result:

probability of severe irritation

Irritant / corrosive response data:

The pure substance caused severe redness of the conjunctivae, secretion of pus, bleeding of the conjunctivae, ciliary injection and severe oedema. Cloudiness of the cornea was still reported at the end of the observation period (day 24).
The 10 and 5% solutions caused redness and swelling of the conjunctivae, which had disappeared 2 to 3 days after exposure.
The 1 and 0.1% solutions caused slight redness of the conjunctivae, which had disappeared 1 day after exposure.

Applicant's summary and conclusion

Interpretation of results:

corrosive