Captan

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 February 1984 to 3 March 1984

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

1981

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EPA OPP 81-2 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Captan

EC Number:

205-087-0

EC Name:

Captan

Cas Number:

133-06-2

Molecular formula:

C9H8Cl3NO2S

IUPAC Name:

2-[(trichloromethyl)sulfanyl]-2,3,3a,4,7,7a-hexahydro-1H-isoindole-1,3-dione

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

- Physical state: white powder
- Purity: 90.5 %
- Batch number: WRC 4921-26-12
- Date of arrival: 13 February 1984

Test animals

Species:

rabbit

Strain:

other: Stauffland albino rabbits

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

three days

Doses:

dose of 2000 mg/kg bw

No. of animals per sex per dose:

5 animals/f/m per dose

Control animals:

yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Clinical signs:

other:

Any other information on results incl. tables

Clinical findings: There were no mortalities. All animals appeared normal throughout the observation period, except two rabbits which had wet areas around the eyes on days 4 and 5.

Local findings: There were no signs of dermal irritation.

Autopsy: No abnormalities were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information In accordance with the provisions of regulation 1272/2008, Annex I, 3.1 classification is not required Criteria used for interpretation of results: EU

Conclusions:

The acute dermal LD50 of captan in rabbits was higher than 2000 mg/kg bw in males and females. In accordance with regulation 1272/2008, Annex I, 3.1 classification is not required

Executive summary:

A single dose of captan was applied to the closely clipped abdominal skin of male and female Stauffland albino rabbits at a dose of 2000 mg/kg bw (5 animals/sex). The skin was abraded on half of the animals and left intact on the others. The area was covered with a protective binder. The binder and test material was removed after 24 hours, the area inspected and rewrapped in a gauze binder. After three days, the gauze binder was removed. A concurrent control (2 animals/sex) was also conducted. All animals were observed for clinical signs for at least 14 days after treatment and were necropsied at the end of the observation period.

Clinical findings: There were no mortalities. All animals appeared normal throughout the observation period, except two rabbits which had wet areas around the eyes on days 4 and 5.

Local findings: There were no signs of dermal irritation.

Autopsy: No abnormalities were observed at necropsy.

Captan was in this study of low toxicity via dermal route of exposure.

Based on this study captan is not classified to be acute toxic for dermal exposure. Nevertheless positive results for sensitisation (Dreher, D.M. 1991) have to be considered leading to classification as skin sensitizing cat. 1 (H317).