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Toxicity to terrestrial arthropods

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Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the toxicity to terrestrial arthropods.

Key value for chemical safety assessment

Additional information

No experimental data evaluating the toxicity of Glycerides, C12-18 di- and tri- (CAS No. 91744-28-4) to arthropods are available. The standard information requirements set in Annex IX of Regulation (EC) No. 1907/2006, Column 2, 9.4, state that short-term toxicity tests on invertebrates should be available. Since earthworm toxicity data are available, showing no toxicity, testing on terrestrial arthropods is not deemed necessary.

 

Earthworm tests conducted on two other category members are used as read-across (in accordance with Regulation (EC) No. 1907.2006, Annex XI, 1.5). Both studies were performed according to OECD 207, showing no effects on survival or biomass of Eisenia fetida after 14 days, leading to NOEC values (14 d) ≥ 1000 mg/kg dw (limit tests) (Muckle, 2012; Moser, 2012).

 

Glycerides, C12-C18, di- and tri- is readily biodegradable. Therefore, rapid and ultimate degradation in the environment, including soil, can be expected. Chronic exposure of terrestrial organisms is thus very unlikely. Due to the metabolization via enzymatic hydrolysis of the Glycerides category members, a relevant uptake and bioaccumulation in biota is not expected. Enzymatic breakdown will initially lead to the free fatty acid and glycerol. Glycerides are naturally stored by organisms as long-term energy reserves. Especially in periods in which the energy demand is high (reproduction, migration, etc.), glycerides are mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species, resulting in the release of acetyl CoA and NADH (throughβ-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. Please refer to IUCLID Section 5.3.1 for a detailed overview on bioaccumulation of the Glycerides category members.

Based on the available information, the chemical safety assessment according to Regulation (EC) No. 1907/2006, Annex I, does not indicate the need to conduct further tests on terrestrial arthropods.