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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

In accordance with column 2 of REACH Annex X, as TAEE is not considered mutagenic and as there is no evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME (2-methoxy-2-methylbutane) and ETBE (2-ethoxy-2-methylpropane), a carcinogenicity study is not needed for TAEE.

Key value for chemical safety assessment

Justification for classification or non-classification

Based on the negative results of the available in vitro genotoxicity studies with TAEE and the absence of evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME and ETBE, classification is not necessary for carcinogenicity in accordance with Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.

Additional information