Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The dermal sensitisation potential of TAEE was assessed in a GLP-compliant murine local lymph node assay (Method B.42 of Commission Directive 2004/73/EEC). In this study, TAEE gave Stimulation Indices less than 3 when tested at concentrations of 100%, 50% or 25% v/v in acetone/olive oil (4:1). Alpha-hexylcinnamaldehyde (positive control substance) gave a Stimulation Index of greater than 3 when tested at 15% v/v in acetone/olive oil (4:1) (Harlan Laboratories Ltd, 2009e).

The results of this study demonstrate that TAEE is not a skin sensitiser.


Migrated from Short description of key information:
TAEE is not a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
Respiratory tract sensitisation is not expected as the substance contains no structural alerts and since no positive human data are available.

Justification for classification or non-classification

Based on the available data, TAEE is considered to be not sensitising. In accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for sensitisation.